Biofilm Pathway & Mechanism Atlas

Multiscale mapping of molecular mechanisms driving the bacterial biofilm lifecycle

Canonical Biofilm Developmental Timeline

Click any stage to filter pathways & featured structural targets

5 Progressive Stages of the Bacterial Biofilm Lifecycle

Molecular Progression of the Biofilm Lifecycle

1. Adhesion 2. EPS Secretion 3. Quorum Sensing 4. c-di-GMP Maturation 5. Active Dispersion

Explore 8 distinct biochemical pathways and 168 macromolecular targets driving each developmental phase, from surface adherence and matrix secretion to quorum sensing regulation and enzymatic matrix dissolution.

All Pathways

Full molecular atlas across all 8 biological pathways of the biofilm cycle.

168 Targets 498 PDBs

Attachment

Initial surface contact, flagellar braking, and fimbrial adhesin anchoring.

TpsB4 FimX SasG

EPS Matrix

Polymerization and export of alginate, Pel, Psl, curli, and PNAG matrix.

PelA PelD AlgG

Quorum Sensing

Cell density-dependent autoinducer signalling (AHL, AI-2, PQS, CAI-1).

LasR RhlR CqsA

c-di-GMP Signalling

Second messenger cyclic-di-GMP metabolizing enzymes and PilZ effectors.

PleD MucR MarR

Active Dispersal

Enzymatic matrix degradation and active detachment of bacterial cells.

BdcA PelA_GH